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KMID : 0364219690120040114
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Korean Journal of Zoology
1969 Volume.12 No. 4 p.114 ~ p.122
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Radioprotective Effect of Methylene Blue: 2. Electron Microscopy of the Effect of Methylene Blue on the Liver and Heart of Rats following Gamma-Irradiation
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Nam Sang-Yul
Chang Seung-Han
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Abstract
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Electron microscopic examination of the liver and heart tissues of methylene blue-treated rats before gamma-irradiation was observed in this study. 1. It was observed severe alteration and degeneration of organelles: accumulation of glycogen particles, severe swollen mitochondria, and broken endoplasmic reticulum in liver tissue of saline-treated rat(control) opposed by emthylene blue-treated rat at 64 and 212 hours following gamma-irradiation. 2. Heart muscles of both methylene blue-treated and saline-treated rats showed no significant alterations, but it was observed that slightly elongated mitochondria with broken cristae and some of vacuoles as well as increased glycogen particles in sarcoplasmic reticulum at 212 hours following gamma-irradiation. 3. It may be considered that methylene blue greatly reduces the sensitivities of rats to gamma-irradiation.
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